Mechanisms of Stationary Phase Mutation: A Decade of Adaptive Mutation
نویسندگان
چکیده
منابع مشابه
The Mutation of the rpoS Gene, the Central Regulator of Stationary Phase, Affects the Cell Division in Flexibacter chinensis
A one kb portion of the rpoS gene from Flexibacter chinensis was isolated by PCR, sequenced and compared to the rpoS gene of a variety of other organisms. The gene was found to be 98% similar to previously sequenced genes. Mutation of the rpoS gene with tri-parental mating produced strain JR101 and the growth rate of the mutant was compared with that of the wild-type. The mutant grew slower, an...
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Stationary-phase mutation in microbes can produce selected ('adaptive') mutants preferentially. In one system, this occurs via a distinct, recombination-dependent mechanism. Two points of controversy have surrounded these adaptive reversions of an Escherichia coli lac mutation. First, are the mutations directed preferentially to the selected gene in a Lamarckian manner? Second, is the adaptive ...
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Stationary phase adaptive mutation in Escherichia coli is thought to be a mechanism by which mutation rates are increased during stressful conditions, increasing the possibility that fitness-enhancing mutations arise. Here we present data showing that the histone-like protein, HU, has a role in the molecular pathway by which adaptive Lac(+) mutants arise in E. coli strain FC40. Adaptive Lac(+) ...
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IN their discussion of mutation in stationary populaTheir data, and that of Rosche and Foster (1999), show that any given class of mutation is z10 times less tions of Escherichia coli, Bull et al. (2000) conclude that all the mutations are arising in a small fraction of common in single (Lac) mutants than in double mutants (Lac plus a second mutation). For example, Torthe population. They give ...
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ژورنال
عنوان ژورنال: Annual Review of Genetics
سال: 1999
ISSN: 0066-4197,1545-2948
DOI: 10.1146/annurev.genet.33.1.57